摘要

A common limitation for the identification of novel activities from functional (meta) genomic screens is the low number of active clones detected relative to the number of clones screened. Here we demonstrate that constructing libraries with strains known to produce bioactives can greatly enhance the screening efficiency, by increasing the. hit-rate. and unmasking multiple activities from the same bacterial source.

  • 出版日期2013-1
  • 单位南阳理工学院