摘要

Direct aldol addition of ketones with aromatic aldehydes and vinyl aldehyde was carried out efficiently in the presence of MgI2 etherate and Et3N using untreated reagent grade CH2Cl2 under atmospheric conditions in a mild, efficient and highly chemoselective manner. Iodide counterion and non-coordinating reaction media (i.e., CH2Cl2) are among the critical factors for the unique reactivity of this reaction system.