Dose-response relationship between visceral fat index and untreated hypertension in Chinese rural population: the RuralDiab study

作者：Tian, Zhongyan; Li, Yuqian; Li, Linlin; Liu, Xiaotian; Shi, Yuanyuan; Yang, Kaili; Liu, Ruihua; Zhang, Honglei; Qian, Xinling; Yin, Lei; Zhao, Jingzhi; Wang, Chongjian^*

来源：Journal of the American Society of Hypertension, 2018, 12(6): 448-456.

DOI：10.1016/j.jash.2018.03.009

• Blood pressure
• rural population
• visceral obesity

The study aimed to explore the association of visceral fat index (VFI) with untreated hypertension in different genders and evaluate the practicability of VFI as a marker for discriminating untreated hypertension in Chinese rural population. A total of 12,536 eligible participants aged 35 years and older were derived from the RuralDiab study in China. VFI was assessed with bioelectrical impendence methods and divided into sex-specific quartiles. Logistic regression and restricted cubic spline regression were performed. Receiver operating characteristic curve was applied to analyze the discriminating performance of VFI. Meanwhile, a meta-analysis was conducted to validate the result of this study. @@@ Compared with the lowest VFI quartile, the adjusted odds ratios (ORs) and 95% confidence interval (95% CI) in the highest VFI quartile were 3.68 (2.91-4.66) in male and 2.63 (2.12-3.25) in female (P-trend < .01). Nonlinear increasing trends about the risk of untreated hypertension were observed with the continuously increasing VFI in both genders (P-linearity < .01). The sensitivity and specificity in the optimal cutoff values for VFI were 58.37% and 62.26% in male, and 49.09% and 66.67% in female. The area under the curves (95% CI) were 0.64 (0.63-0.66) in male and 0.61 (0.60-0.62) in female. Meta-analysis results displayed the pooled odds ratios (95% CI) of 2.65 (1.79-3.93) in male and 2.27 (1.74-2.95) in female. VFI was significantly positively correlated with the risk of untreated hypertension, and dose-response relationships were observed in both genders in Chinese rural population. However, VFI as a marker had limited potential for discriminating untreated hypertension.

• 出版日期2018-6
• 单位郑州大学