科研之友
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摘要
The species of Alkanna is used in Iranian traditional medicine for treatment of rheumatoid arthritis and other inflammatory diseases. This study was designed to evaluate the anti-inflammatory and anti-nociceptive effects of Alkanna frigida and Alkanna orientalis ethanolic extracts via carrageenan-induced paw edema test and formalin test in rat and mice, respectively. Ethanolic extracts of plants root were prepared and were intraperitoneally injected 60 min before carrageenan-induced inflammation or formalin-induced nociception at 100, 200 and 400 mg/kg. Anti-inflammatory effects of plants were monitored during 3 h after carrageenan injection and anti-nociceptive effects of them were evaluated during the first hour after formalin injection. Diclofenac a well-known anti-inflammatory and anti-nociceptive agent was used as a positive control. Our results show in contrast to Alkanna orientalis, ethanolic extract of Alkanna frigida significantly decreases the carrageenan-induced inflammation at 400 mg/kg especially 3 h after inflammation induction. Both Alkanna frigida and Alkanna orientalis ethanolic extract possess a remarkable anti-nociceptive effect at each doses (100, 200 and 400 mg/kg) in a dose dependent manner during the first hour after formalin injection. The present finding provides more evidence for potential anti-nociceptive effect of Alkanna sp. and anti-inflammation effect of Alkanna frigida. It can describe the traditional indication of them in treatment of pain and inflammatory-related diseases. These useful effects can be resulted from inhibitory interaction of plant ethanolic extract with cyclooxygenase-2 enzyme and subsequently reduction in prostaglandins production.
- 出版日期2012-7
