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摘要
Background: This study was to determine age-specific impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors (BOTs). Patients diagnosed during 1988-2000 were selected from The Surveillance, Epidemiology, and End Results (SEER) database. The age-specific impact of fertility preserving surgery and other risk factors were analyzed in patients with stage I BOTs using Cox proportion hazard regression models. Data from our hospital were collected during 1996-2017 to determine the prevalence of patients who had undergone fertility preserving surgery. Results: Of a total 6295 patients in the SEER database, this study selected 2946 patients with stage T1 BOTs who underwent fertility preserving or radical surgery. Their median age at diagnosis was 45.0 years and the median follow-up time was 200 months. Fertility preserving surgery was performed in 1000/1751 (57.1%) patients < 50 years and in 1,81/1195 (15.1%) patients >= 50 years. Fertility preserving surgery was significantly associated with worse disease-specific survival only in patients >= 50 years. Increased age, stage T1c and mucinous histology were risk factors for overall patients or patients >= 50 years, but not for < 50 years. Data from our hospital showed that fertility preserving surgery was performed in 53.9 and 12.3% patients < 50 and >= 50 years with stage I disease, respectively. Conclusion: Fertility preserving surgery is safe for women < 50 years with early staged BOTs, but it may decrease disease-specific survival in patients >= 50 years. Conservative surgery is performed at a relatively high rate in patients >= 50 years.
- 出版日期2018-6-29
- 单位浙江省肿瘤医院
