MR T2 value of the tibial nerve can be used as a potential non-invasive and quantitative biomarker for the diagnosis of diabetic peripheral neuropathy

作者：Wang, Dongye; Wang, Chuan; Duan, Xiaohui; Yang, Zehong; Bai, Zhiqiang; Hu, Huijun; Yan, Li^*; Shen, Jun^*

来源：European Radiology, 2018, 28(3): 1234-1241.

DOI：10.1007/s00330-017-5043-1

• Peripheral nervous system diseases
• Diabetes mellitus
• Diabetic neuropathies
• Magnetic resonance imaging
• Tibial nerve

To determine the role of quantitative tibial nerve T2 value in the diagnosis of diabetic peripheral neuropathy (DPN). @@@ MR imaging and T2 mapping of the tibial nerve were performed in 22 diabetic patients with DPN, 20 diabetic patients without DPN and 20 healthy controls. Nerve T2 values were measured, and compared using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic ability of T2 value to identify DPN. @@@ Nerve T2 value was 55.06 +/- 4.05 ms, 48.91 +/- 3.06 ms and 45.61 +/- 1.86 ms in patients with DPN, patients without DPN and controls, respectively. Patients with DPN had significantly higher nerve T2 values than patients without DPN (P < 0.001). Nerve T2 values in patients without DPN were higher than in controls (P < 0.001). ROC analysis showed that T2 values had a diagnostic sensitivity of 81.8 %, specificity of 89.2 % and area under the curve of 0.922 for identifying patients with DPN from patients without DPN plus controls when the cutoff point was 51.34 ms. @@@ T2 value of the tibial nerve can be used as an alternative, non-invasive quantitative parameter to assess DPN in diabetic patients.

• 出版日期2018-3
• 单位中山大学