Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating

作者：Caglayan Humeyra^*; Cakmakyapan Semih; Addae Sarah A; Pinard Melissa A; Caliskan Deniz; Aslan Kadir; Ozbay Ekmel

来源：Applied Physics Letters, 2010, 97(9): 093701.

DOI：10.1063/1.3484958

In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures.

• 出版日期2010-8-30