Assessment of palliative care for advanced non-small-cell lung cancer in France: A prospective observational multicenter study (GFPC 0804 study)

作者：Vergnenegre Alain^*; Hominal Stephane; Tchalla Achille Edem; Berard Henri; Monnet Isabelle; Fraboulet Gislaine; Baize Nathalie; Audigier Valette Clarisse; Robinet Gilles; Oliviero Gerard; Le Caer Herve; Thomas Pascal; Geriniere Laurence; Mastroianni Benedicte; Chouaid Christos

来源：Lung Cancer, 2013, 82(2): 353-357.

DOI：10.1016/j.lungcan.2013.07.014

• Palliative care
• Non-small-cell lung cancer
• Observational study
• Quality of care
• Economics

Introduction: Few studies assessed, in real life, symptoms, specific interventions and factors influencing palliative care (PC) initiation for patients with advanced non-small-cell lung cancer (NSCLC). The objective of this study was to examine, in a prospective cohort of advanced NSCLC patients, PC use and factors associated with early (<= 3 months after diagnosis) PC initiation.
Methods: It was an observational multicenter study. Each center included 10 consecutive patients with PC initiation.
Results: 514 patients were enrolled by 39 centers (age: 62.3 +/- 10.7 years, performance status: 0/1; 68.6% cases). At baseline, the most frequent symptoms concerned pain (43.6%), malnutrition (37%) and psychological disorders (25.3%). Specific interventions were infrequent for pain control and malnutrition, but were more numerous for psychological and social problems and terminal care. Median time between diagnosis and PC initiation was 35 [13-84] days, median PC duration was 4.2 [0.6-9.3] months. Median overall survival was 8.6 [6.6-10.7] months; median survival after PC initiation was 3.6 [3.2-4.5] months. In multivariate analysis, only PS >= 2 was linked to early PC.
Conclusion: This study showed that early PC initiation is not a standard for patients with advanced NSCLC.

• 出版日期2013-11