Diagnosis-specific characteristics of ventricular tachycardia in children with structurally normal hearts

作者：Wang, Samuel; Zhu, Wei; Hamilton, Robert M; Kirsh, Joel A; Stephenson, Elizabeth A; Gross, Gil J^*

来源：Heart Rhythm, 2010, 7(12): 1725-1731.

DOI：10.1016/j.hrthm.2010.07.037

• Arrhythmia
• Ventricular tachycardia
• Infants
• Children
• Adolescents
• Sudden death

BACKGROUND Improved mechanistic insights and clinical tools provide increasing diagnostic refinement for ventricular tachycardia in young patients with structurally normal hearts, yielding potentially important prognostic and management implications.
OBJECTIVE The purpose of this study was to survey the clinical characteristics and outcomes of otherwise healthy children with ventricular tachycardia (VT) who were classified according to contemporary diagnostic criteria.
METHODS A single-center retrospective review of patients younger than 18 years of age with VT diagnosed between January 1980 and December 2005 was undertaken. Patients with significant systemic illness or with underlying structural or functional heart disease were excluded.
RESULTS A total of 77 patients met inclusion criteria and were grouped as follows: accelerated idioventricular rhythm (AIVR; n = 19), right ventricular tachycardia (RVT; n = 30), left ventricular tachycardia (LVT; n = 23), and catecholamine sensitive polymorphic VT (CPVT; n = 5). AIVR patients were youngest at diagnosis and had the most benign natural history, while the opposite was true of CPVT patients. Ablation was attempted in 2/30 RVT (50% success) and 10/23 LVT (80% success) patients. Severe cardiac events occurred in 3/23 LVT (no deaths) and 2/5 CPVT (one death) patients.
CONCLUSION The natural history and appropriate management of VT in young patients with structurally normal hearts are highly dependent on the specific diagnosis. LVT and CPVT are associated with significantly greater morbidity and mortality than AIVR and RVT.

• 出版日期2010-12
• 单位上海交通大学