Antimicrobial activities of fungi derived from the gorgonian sea fan Annella sp & their metabolites

作者：Preedanon Sita; Phongpaichit Souwalak^*; Sakayaroj Jariya; Rukachaisirikul Vatcharin; Khamthong Nanthaphong; Trisuwan Kongkiat; Plathong Sakanan

来源：Indian Journal of Marine Sciences, 2016, 45(11): 1491-1498.

• Sea fan-derived fungi
• antibacterial
• antifungal
• molecular identification
• griseofulvin

One hundred and sixty-three fungi isolated from gorgonian sea fan Annella sp. were screened for antimicrobial activity against human pathogens. Forty-seven percents of the isolates produced antimicrobial metabolites against at least one pathogen with minimum inhibitory concentrations (MIC) ranged from 1 to 1,280 mu g mL(-1). Crude extracts from 16%, 21%, 18% and 23% of the isolates inhibited standard strain of Staphylococcus aureus, methicillin-resistant S. aureus, Escherichia colt and Pseudomonas aeruginosa, respectively. Eighteen percents of the isolates displayed antifungal activity against Microsporum gypseum while only 3% inhibited Czyptoccocus neoformans and Candida albicans. Potential isolates were identified by morphological and molecular characteristics. Twenty-nine pure compounds isolated from ten isolates were evaluated for antimicrobial activity. Griseofulvin from Nigrospora sp. PSU-F13 exhibited the best activity against M gypseum (MIC 2 mu g mL(-1)). The result indicates that sea fan-derived fungi are a potential source of antimicrobial agents.

• 出版日期2016-11