Amorphous metal-organic frameworks for drug delivery

作者：Orellana-Tavra, Claudia; Baxter, Emma F.; Tian, Tian; Bennett, Thomas D.; Slater, Nigel K. H.; Cheetham, Anthony K.; Fairen-Jimenez, David^*

来源：Chemical communications, 2015, 51(73): 13878-13881.

DOI：10.1039/c5cc05237h

• DOXORUBICIN
• CARRIERS

We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

• 出版日期2015