科研之友
微信
新浪微博
Facebook
分享链接
摘要
Both cis- and trans-3-hydroxy-L-pipecolic acids are synthesized from a common chiral intermediate 7 by a short and flexible route. The stereospecific inversion of C-3 was achieved by the formation of an oxazoline followed by acidic ring cleavage. The overall yields are 27% and 30%, respectively, in 12 and 10 linear steps. Several versatile chiral building blocks are also accessible by this diastereodivergent synthesis. Unlike the chiral pool approach, our synthetic strategy is not limited by the availability of starting materials.
- 出版日期2009-6
- 单位复旦大学
