D-Glucuronic Acid Coated Gd(IO3)3 center dot 2H2O Nanomaterial as a Potential T1 MRI-CT Dual Contrast Agent

作者：Lee Eun Jung; Heo Woo Choul; Park Jang Woo; Chang Yongmin^*; Bae Ji Eun; Chae Kwon Seok; Kim Tae Jeong; Park Ji Ae; Lee Gang Ho

来源：European Journal of Inorganic Chemistry, 2013, (16): 2858-2866.

DOI：10.1002/ejic.201201481

• Nanostructures
• Nanomaterials
• Imaging agents
• Lanthanides

To date, only a few nanosystems have been investigated as T1 MRI-CT dual contrast agents. The T1 MRI-CT dual functionality of a material depends on its longitudinal water-proton relaxivity (r1) and X-ray absorption strength. We explored Gd(IO3)3 center dot 2H2O nanomaterial because Gd is the most powerful element for T1 MRI contrast agents, and both Gd and I absorb X-ray radiation; Gd absorbs X-ray radiation ca. 2.5 times more strongly than I. D-Glucuronic acid coated Gd(IO3)3 center dot 2H2O nanomaterial showed a very large r1 of 52.3 s1mM1 (r2/r1 = 1.21), which could be ascribed to hydrated water molecules in the lattice. Its X-ray absorption intensity was also stronger than those of commercial molecular iodine CT contrast agents. This result clearly suggests that D-glucuronic acid coated Gd(IO3)3 center dot 2H2O nanomaterial is a potential T1 MRI-CT dual contrast agent.

• 出版日期2013-6
• 单位南宁师范大学