Stem cell therapies for type 1 diabetes mellitus

作者:Voltarelli Julio C*; Couri Carlos E B; Rodrigues Maria C; Moraes Daniela A; Stracieri Ana Beatriz P L; Pieroni Fabiano; Navarro George; Leal Angela M O; Simoes Belinda P
来源:Indian Journal of Experimental Biology, 2011, 49(6): 395-400.

摘要

The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.

  • 出版日期2011-6