A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: A longitudinal, randomized, crossover, double-blind, placebo-controlled nutritional intervention study

作者：Zulet M A; Nayas Carretero S; Lara y Sanchez D; Abete I; Flanagan J; Issaly N; Fanca Berthon P; Bily A; Roller M; Martinez J A^*

来源：Phytomedicine, 2014, 21(10): 1162-1169.

DOI：10.1016/j.phymed.2014.04.027

• Fraxinus excelsior L.
• Impaired glucose tolerance
• Diabetes
• Obesity
• Herbal medicine
• Fructosamine

Purpose: The aim of this study was to investigate the potential benefits of an extract obtained from seeds/fruits of an Oleaceae (Fraxinus excelsior L.) on glucose homeostasis and associated metabolic markers in non-diabetic overweight/obese subjects. %26lt;br%26gt;Materials and methods: This study was performed in 22 participants (50-80 years-old; BMI 31.0 kg/m(2)). The design was a longitudinal, randomized, crossover, double-blind, placebo-controlled 7-week nutritional intervention. The participants received daily 3 capsules each containing either 333 mg of an extract from Fraxinus excelsior L. seeds (Glucevia (R)) or placebo capsules (control) in a random order for 3 weeks with 1 week of washout between treatments. Moreover, they followed a balanced covert energy-restricted diet (-15% energy). All variables were measured at the beginning and at the end of each period. %26lt;br%26gt;Results: Compared to baseline, the administration of 1 g of Glucevia (R) for 3 weeks resulted in significantly lower incremental glucose area under the curve (-28.2%; p %26lt; 0.01), and significantly lower 2 h blood glucose values (-14%; p %26lt; 0.01) following an oral glucose tolerance test. No significant changes were found in the control group (-7.9% AUC, -1.6% 2 h blood glucose). Furthermore, significant differences were found between responses in the control and Glucevia (R) groups with respect to serum fructosamine and plasma glucagon levels (p %26lt; 0.01 and p %26lt; 0.05, respectively). Interestingly, administration of Glucevia significantly increased the adiponectin:leptin ratio (p %26lt; 0.05) and decreased fat mass (p %26lt; 0.01) compared to control (p %26lt;0.05). %26lt;br%26gt;Conclusion: The administration of an extract from Fraxinus excelsior L. seeds/fruits in combination with a moderate hypocaloric diet may be beneficial in metabolic disturbances linked to impaired glucose tolerance, obesity, insulin resistance and inflammatory status, specifically in older adults.

• 出版日期2014-9