Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway

作者：Shen, Cheng; Wang, Cong; Fan, Fan; Yang, Zhiyin; Cao, Quan; Liu, Xiangwei; Sun, Xiaolei; Zhao, Xiaona; Wang, Peng; Ma, Xin; Zhu, Hong; Dong, Zhen; Zou, Yunzeng; Au, Kai; Sun, Aijun^*; Ge, Junbo

来源：Biochimica et Biophysica Acta-Molecular Basis of Disease, 2015, 1852(2): 310-318.

DOI：10.1016/j.bbadis.2014.07.014

• ALDH2
• Pressure overload
• Heart failure
• Autophagy
• Beclin-1

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) was demonstrated to play cardioprotective roles in cardiovascular diseases. Nonetheless, little is known about the roles and mechanisms of ALDH2 in pressure overload-induced cardiac damages. In this study, we revealed that ALDH2 deficiency overtly exacerbated transverse aortic constriction (TAC)-induced cardiac dysfunction. Cardiomyocyte enlargement was observed in both WT and ALDH2-/- mice in HE-stained myocardial tissue samples at 8 weeks post TAC surgery. Mitochondrial morphology and structure were also significantly damaged post TAC surgery and the changes were aggravated in ALDH2-/- TAC hearts. ALDH2 deficiency also depressed myocardial autophagy in hearts at 8 weeks post TAC surgery with a potential mechanism of repressing the expression of Bedin-1 and promoting the interaction between Bcl-2 and Bedin-1. These data indicate that ALDH2 deficiency exacerbates the pressure overload induced cardiac dysfunction partly by inhibiting Beclin-1 dependent autophagy pathway. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.

• 出版日期2015-2
• 单位复旦大学