A bioactive diterpene from Entada abyssinica

作者：Tchinda Alembert T^*; Fuendjiep Victorine; Mekonnen Yalemtsehay; Ngo Bernadette B; Dagne Ermias

来源：Natural Product Communications, 2007, 2(1): 9-12.

• Entada abyssinica
• Leguminosae
• kolavic acid 18-methyl ester
• antimicrobial
• antileishmanial

Three clerodane diterpenolds, 8S-kolavic acid 18-methyl ester (1), 8S-kolavic acid 15-methyl ester (2) and 8S-kolavenol (3) were isolated from the acetone extract of the stem bark of Entada abyssinica along with trans-communic acid (4) and 1-octacosanol. Their structures were established mainly based on ID (H-1, C-13 and DEPT) and 2D (H-1-H-1 COSY, HSQC and HMBC) NMR experiments. Compound 1, described here for the first time, showed strong antimicrobial and moderate antileishmanial activities.

• 出版日期2007
• 单位河北医科大学