Down-regulation of GnT-V inhibits nasopharyngeal carcinoma cell CNE-2 malignancy in vitro and in vivo

作者：Wei, Ting; Li, Yahui; Zhuo, Enqing; Zhu, Weiliang; Meng, Hui; Zhang, Jian^*

来源：Cancer Letters, 2011, 309(2): 151-161.

DOI：10.1016/j.canlet.2011.05.029

• Nasopharyngeal carcinoma
• N-acetylglucosaminyltransferases V
• Malignancy

To investigate the role of N-acetylglucosaminyltransferases V (GnT-V) in the development of human nasopharyngeal carcinoma (NPC) both in vitro and in vivo, the GnT-V stably suppressed cell line CNE-2 GnT-V/2224 was constructed from CNE-2. The studies indicated that down-regulation of GnT-V inhibited the proliferation, migration and invasion abilities of the NPC cell line CNE-2. The radio sensitivity of CNE-2 was enhanced after down-regulation of GnT-V, which may be associated with the decreased expression of bcl-2.

• 出版日期2011-10-28
• 单位南方医科大学