Association of pericoronary fat volume with atherosclerotic plaque burden in the underlying coronary artery: A segment analysis

作者：Mahabadi Amir A; Reinsch Nico; Lehmann Nils; Altenbernd Jens; Kaelsch Hagen; Seibel Rainer M; Erbel Raimund; Moehlenkamp Stefan

来源：Atherosclerosis, 2010, 211(1): 195-199.

DOI：10.1016/j.atherosclerosis.2010.02.013

• Pericoronary fat
• Pericardial fat
• Visceral fat
• Coronary artery disease
• Dual-source computed tomography

Objective: We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment.
Methods: We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. For pericoronary fat evaluation, regions of interest were manually traced containing any fat surrounding a coronary artery segment, with the myocardial wall, the pericardial sac and other coronary segments as outer border.
Results: Per each doubling of pericoronary fat volume, we observed an 2.5-fold increase in the presence of plaque in the underlying coronary segment in unadjusted models (95% confidence interval [CI] 1.87-3.27, p < 0.001), which remained after adjustment for traditional cardiovascular risk factors (odds ratio [OR] 3.07 [2.16-4.35], p < 0.001) and when additionally accounting for overall pericardial fat volume (OR 2.68 [1.90-3.79], p < 0.001). Associations were similar in all coronary artery segments and not related to the type of plaque (calcified or non-calcified, p < 0.01 for all).
Conclusion: Pericoronary fat is associated with atherosclerosis in the coronary arteries. Our results support the hypothesis that perivascular fat depots may function as a local endocrine risk factor in atherosclerosis development.

• 出版日期2010-7
• 单位河北医科大学