Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study

作者：Kolla Nathan J; Dunlop Katharine; Downar Jonathan; Links Paul; Bagby R Michael; Wilson Alan A; Houle Sylvain; Rasquinha Fawn; Simpson Alexander I; Meyer Jeffrey H

来源：European Neuropsychopharmacology, 2016, 26(4): 777-786.

DOI：10.1016/j.euroneuro.2015.12.030

• Antisocial personality disorder
• Monoamine oxidase-A
• Positron emission tomography
• Functional magnetic resonance imaging
• Impulsivity
• Violence

Impulsivity is a core feature of antisocial personality disorder (ASPD) associated with abnormal brain function and neurochemical alterations. The ventral striatum (VS) is a key region of the neural circuitry mediating impulsive behavior, and low monoamine oxidase-A (MAO-A) level in the VS has shown a specific relationship to the impulsivity of ASPD. Because it is currently unknown whether phenotypic MAO-A markers can influence brain function in ASPD, we investigated VS MAO-A level and the functional connectivity (FC) of two seed regions, superior and inferior VS (VSs, VSi). Nineteen impulsive ASPD males underwent [C-11] harmine positron emission tomography scanning to measure VS MAO-A V-T, an index of MAO-A density, and resting state functional magnetic resonance imaging that assessed the FC of bilateral seed regions in the VSi and VSs. Subjects also completed self-report impulsivity measures. Results revealed functional coupling of the VSs with bilateral dorsomedial prefrontal cortex (DMPFC) that was correlated with VS MAO-A V-T (r=0.47, p=0.04), and functional coupling of the VSi with right hippocampus that was anti-correlated with VS MAO-A V-T (r=-0.55, p=0.01). Additionally, VSs-DMPFC FC was negatively correlated with NEO Personality Inventory-Revised impulsivity (r=0.49, p=0.03), as was VSi-hippocampus FC with Barratt Impulsiveness Scale-11 motor impulsiveness (r= 0.50, p=0.03). These preliminary results highlight an association of VS MAO-A level with the FC of striatal regions linked to impulsive behavior in ASPD and suggest that phenotype-based brain markers of ASPD have relevance to understanding brain function.

• 出版日期2016-4
• 单位河北医科大学