A geometric approach for adaptive estimation of unknown growth kinetics in bioreactors

作者：Moshksar Ehsan; Guay Martin^*

来源：Journal of Process Control, 2014, 24(10): 1496-1503.

DOI：10.1016/j.jprocont.2014.06.017

• Invariant manifold
• Growth kinetics
• Adaptive estimation
• Asymptotic observer

This paper proposes a new approach for the estimation of unknown and time-varying specific growth rate in fed-batch bioprocess. A novel adaptive estimation technique based on the concept of invariant manifold is proposed as an effective approach to estimate growth kinetic parameters. An asymptotic nonlinear observer is used to provide simultaneous on-line estimation of biomass concentration and growth kinetic. The method is easy to implement and requires only one tuning parameter. The effectiveness of the proposed algorithm is illustrated with representative bioreactor simulation examples.

• 出版日期2014-10