Apoptotic Signal Pathways of Tumor Cells Induced by Ruthenium Complexes and Its Mechanisms

作者：Zhang Xiaonian; Liu Yanan; Yang Xiaoxin; Liu Jie^*

来源：Progress in Chemistry, 2011, 23(5): 983-990.

• ruthenium complexes
• anti-tumor activity
• apoptosis
• signaling pathway
• protein regulation of apoptosis

As anticancer drugs, ruthenium complexes have received wide attention at home and abroad. In recent years, the design and synthesis of new types of complexes, the regulatory role of complexes in apoptosis, signal transduction, and gene expression have become a new hotspot, and its mechanisms of anticancer activity of metal complexes have been further explained. This paper mainly reviews ruthenium complexes, including their effect to induce the apoptosis of various types of tumor cell and their mechanism that induces apoptosis in current studies. The main text includes the following; the anti-cancer mechanism of the ruthenium complexes which had accessed to clinical (I, II); the cell cycle arrest induced by ruthenium complexes; the endogenous mitochondrial damage, the endoplasmic reticulum stress and other signal transduction pathway which induced tumor cell apoptosis; regulating the expression of the pathway-related proteins; regulating the expression and activity of these proteins which are related to the cell apoptosis or the cell proliferation.

• 出版日期2011-5-24
• 单位暨南大学