科研之友
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摘要
This study investigated the effects of diabetic rats induced by streptozotocin (STZ) on acetone concentration emanating from the tail of a rat. Experiments were carried out with male Wistar rats (9 weeks of age, 220 - 250 g body weight). Glucose concentration in the blood was 10.8 +/- 0.7 mmol/l for the control group and 39.6 +/- 2.4 mmol/l for the diabetic group. beta-Hydroxybutyrate concentration in blood was 218 +/- 52 mu mol/l for the control group and 1439 +/- 101 mu mol/l for the diabetic group. Both glucose and beta-hydroxybutyrate concentrations in the blood of the diabetic group were significantly higher than those of the control group (p %26lt; 0.001). Skin gas acetone concentration emanated from rat tail was 124 +/- 46 ppb for control and 1134 +/- 417 ppb for diabetic. Skin gas acetone concentration emitted from the tail of a rat with diabetes was significantly higher than that from a rat in the control group (p %26lt; 0.001). The result indicates that skin acetone emanating from a rat tail is a useful parameter to use for insulin-dependent diabetes (type I).
- 出版日期2012-5
