The role of delayed gastric emptying and impaired oesophageal body motility

作者：Penagini Roberto^*; Bravi Ivana

来源：Best Practice & Research in Clinical Gastroenterology, 2010, 24(6): 831-845.

DOI：10.1016/j.bpg.2010.09.003

• Gastro oesophageal reflux disease
• Gastric emptying
• Oesophageal motility

Delayed gastric emptying in a variable proportion of patients with gastro-oesophageal reflux disease has been observed in most series however a relationship between delayed gastric emptying and increased gastro-oesophageal reflux has not been convincingly demonstrated Enhanced postprandial accommodation and delayed emptying of the proximal stomach have been described but some controversy exists Impaired primary peristalsis is often present especially in patients with oesophagitis and its prevalence increases with increasing severity of inflammatory mucosal lesions Patients with gastro-oesophageal reflux disease often have defective triggering of secondary peristalsis independently of presence of oesophagitis It is presently unclear if impaired oesophageal motility is a primary defect or an irreversible consequence of inflammation Attempts it pharmacological improvement of impaired oesophageal motility have

• 出版日期2010-12