A facile one-step method for preparation of Fe3O4/CS/INH nanoparticles as a targeted drug delivery for tuberculosis

作者：Zhao, Chili; Liu, Xun; Zhang, Xia; Yan, Hong; Qian, Zhilei; Li, Xinghui; Ma, Zhenye^*; Han, Qiaorong^*; Pei, Chonghua^*

来源：Materials Science and Engineering: C , 2017, 77: 1182-1188.

DOI：10.1016/j.msec.2017.03.137

• Magnetic nanoparticles
• Chitosan
• Magnetic targeted drug delivery system
• Isoniazid
• Orthogonal experiments

In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.

• 出版日期2017-8-1
• 单位南京师范大学; 西南科技大学; 南京市胸科医院