Asprosin, a Fasting-Induced Glucogenic Protein Hormone

作者：Romere Chase; Duerrschmid Clemens; Bournat Juan; Constable Petra; Jain Mahim; Xia Fan; Saha Pradip K; Del Solar Maria; Zhu Bokai; York Brian; Sarkar Poonam; Rendon David A; Gaber M Waleed; LeMaire Scott A; Coselli Joseph S; Milewicz Dianna M; Sutton V Reid; Butte Nancy F; Moore David D; Chopra Atul R^*

来源：Cell, 2016, 165(3): 566-579.

DOI：10.1016/j.cell.2016.02.063

Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation. Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release. Asprosin represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type II diabetes and metabolic syndrome.

• 出版日期2016-4-21