Activation of the NC-H bond of Baylis-Hillman adducts of N-methylisatin with CAN/ROH

作者：Shanmugam Ponnusamy^*; Vaithiyanathan Vadivel; Viswambharan Baby

来源：Tetrahedron Letters, 2006, 47(38): 6851-6855.

DOI：10.1016/j.tetlet.2006.07.070

• CAN
• Baylis-Hillman adduct
• CH-activation
• isatin
• functionalized ethers

A facile method for activation of the NC-H bond of N-methylisatin and Baylis-Hillman adducts of N-methylisatin with cerium ammonium nitrate (CAN) and saturated and unsaturated alcohols is reported. Adducts bearing an ester group at the activated alkene afford functionalized ethers, while those with a nitrile afforded ethers and nitrated aromatic products in good yield.

• 出版日期2006-9-18