Emerging roles of DNA-PK besides DNA repair

作者：Kong, Xianming; Shen, Ying; Jiang, Na; Fei, Xin; Mi, Jun^*

来源：Cellular Signalling, 2011, 23(8): 1273-1280.

DOI：10.1016/j.cellsig.2011.04.005

• DNA-PK
• Cell proliferation
• DNA repair
• Gene regulation

The DNA-dependent protein kinase (DNA-PK) is a DNA-activated serine/threonine protein kinase, and abundantly expressed in almost all mammalian cells. The roles of DNA-PK in DNA-damage repair pathways, including non-homologous end-joining (NHEJ) repair and homologous recombinant (HR) repair, have been studied intensively. However, the high levels of DNA-PK in human cells are somewhat paradoxical in that it does not impart any increased ability to repair DNA damage. If DNA-PK essentially exceeds the demand for DNA damage repair, why do human cells universally express such high levels of this huge complex? DNA-PK has been recently reported to be involved in metabolic gene regulation in response to feeding/insulin stimulation; our studies have also suggested a role of DNA-PK in the regulation of the homeostasis of cell proliferation. These novel findings expand our horizons about the importance of DNA-PK.

• 出版日期2011-8
• 单位河北医科大学; 上海交通大学