Antitumor efficacy of poly(brassylic acid-pentadecandioic acid) copolymer

作者：Guo, Wen xun^*; Long, Ze jun; Zhang, Zhi; Hu, Lixin

来源：Materials Science and Engineering: C , 2007, 27(1): 51-56.

DOI：10.1016/j.msec.2006.01.005

• poly(brassylic acid-pentadecandioic acid) copolymer
• drug release
• adriamycin hydrochloride
• antitumor efficacy
• biocompatibility
• sarcoma-180 tumor

The drug release profiles of poly(brassylic acid-pentadecandioic acid) P(BA-PA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The surface structure of P(BA-PA) copolymer and its drug-loading wafers were studied by atomic force microscopy (AFM). The biocompatibility of P(BA-PA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(BA-PA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (25 +/- 1.0 days) compared to plain subcutaneous injection of ADM (7 +/- 0.9 days). The studies suggest that P(BA-PA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors.

• 出版日期2007-1
• 单位湖北工业大学; 湖南大学