Mouse Myocardial First-Pass Perfusion MR Imaging

作者：Coolen Bram F; Moonen Rik P M; Paulis Leonie E M; Geelen Tessa; Nicolay Klaas; Strijkers Gustav J^*

来源：Magnetic Resonance in Medicine, 2010, 64(6): 1658-1663.

DOI：10.1002/mrm.22588

• mouse cardiac MRI
• first-pass
• perfusion
• Gd-DTPA
• myocardial infarction

A first-pass myocardial perfusion sequence for mouse cardiac MRI is presented. A segmented ECG-triggered acquisition combined with parallel imaging acceleration was used to capture the first pass of a Gd-DTPA bolus through the mouse heart with a temporal resolution of 300-400 msec. The method was applied in healthy mice (N = 5) and in mice with permanent occlusion of the left coronary artery (N = 6). Baseline semiquantitative perfusion values of healthy myocardium showed excellent reproducibility. Infarct regions revealed a significant decrease in the semiquantitative myocardial perfusion values (0.05 +/- 0.02) compared to remote myocardium (0.20 +/- 0.04). Myocardial areas of decreased perfusion correlated well to infarct areas identified on the delayed-enhancement scans. This protocol is a valuable addition to the mouse cardiac MRI toolbox for preclinical studies of ischemic heart disease. Magn Reson Med 64:1658-1663, 2010.

• 出版日期2010-12