Asymmetric Total Synthesis of (-)-Galanthamine via Intramolecular Heck Reaction of Conjugated Diene

作者：Choi Juhee; Kim Hyunseok; Park Sangyun; Tae Jinsung^*

来源：Synlett, 2013, 24(3): 379-382.

DOI：10.1055/s-0032-1317791

• epoxides
• (-)-galanthamine
• Heck reaction
• metathesis
• total synthesis

Asymmetric total synthesis of (-)-galanthamine was accomplished starting from an epoxide. Intramolecular Heck reaction of a conjugated diene system was employed to construct the key quaternary carbon center. The cyclohexene-1,3-diol unit of (-)-galanthamine is derived from an optically active epoxy alkenol.

• 出版日期2013-2