Bladder Pain Syndrome/Interstitial Cystitis Is Associated With Anxiety Disorder

作者：Chung Kuo Hsuan; Liu Shih Ping; Lin Herng Ching; Chung Shiu Dong^*

来源：Neurourology and Urodynamics, 2014, 33(1): 101-105.

DOI：10.1002/nau.22382

• bladder pain syndrome
• interstitial cystitis
• interstitial cystitis
• rheumatoid arthritis

AimRecent research demonstrated that bladder pain syndrome/interstitial cystitis (BPS/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS/IC using a case-controlled population-based approach in Taiwan. %26lt;br%26gt;MethodsData on the sampled subjects analyzed in this study were retrieved from the Longitudinal Health Insurance Database 2000. Our study included 396 female cases with BPS/IC and 1,980 randomly selected female controls. We excluded subjects who had a history of major psychosis (except AD) or a substance-related disorder. A conditional logistic regression was performed to calculate the odds ratio (OR) for the association between a previous diagnosis of AD and IC/BPS. %26lt;br%26gt;ResultsOf the 2,376 sampled subjects, 136 (5.72%) had received an AD diagnosis. AD was found in 64 (16.16%) cases and in 72 (3.64%) controls (P%26lt;0.001). The conditional logistic regression analysis (conditioned on age group and the index year) suggested that compared to controls, the OR for prior AD among cases was 4.59 (95% confidence interval (CI)=2.32-9.08, P%26lt;0.001). After adjusting for chronic pelvic pain, irritable bowel syndrome, fibromyalgia, migraines, sicca syndrome, allergies, asthma, and an overactive bladder, the OR for prior AD among cases was 4.37 (95% CI=2.16-8.85, P%26lt;0.001) compared to the controls. %26lt;br%26gt;ConclusionsThere was an association between AD and BPS/IC, even after taking demographic characteristics, medical co-morbidities, and substance-related disorders into consideration. Results of this study should alert clinicians to evaluate and monitor the presence of BPS/IC in patients with AD. Neurourol. Urodynam. 33:101-105, 2014.

• 出版日期2014-1