Neurosyphilis presenting as mania

作者：Barbosa Izabela Guimaraes^*; Vale Thiago Cardoso; de Macedo Daniela Lino; Gomez Rodrigo Santiago; Teixeira Antonio Lucio

来源：Bipolar Disorders, 2012, 14(3): 309-312.

DOI：10.1111/j.1399-5618.2012.01007.x

• bipolar disorder
• general paresis of the insane
• neurosyphilis
• Treponema pallidum

Barbosa IG, Vale TC, de Macedo DL, Gomez RS, Teixeira AL. Neurosyphilis presenting as mania. Bipolar Disord 2012: 14: 309312. (C) 2012 The Authors. Journal compilation (C) 2012 John Wiley %26 Sons A/S. Objective: General paresis of the insane is a late and severe form of neurosyphilis characterized by nonspecific neuropsychiatric symptoms. There are a limited number of case reports of mood disorders presenting in neurosyphilis, with depressive illness being the most common. Methods: We performed a literature review of case reports of secondary bipolar disorder induced by syphilitic infection. Results: Herein reported is a case of a 53-year-old woman who initially presented with symptoms of mania and depression, mimicking bipolar disorder, but was subsequently diagnosed with general paresis of the insane. Conclusion: The present case report emphasizes that if a substantial delay occurs in syphilis diagnosis and management, the patient may have a very poor prognosis.

• 出版日期2012-5