Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

作者：Williet Nicolas^*; Dubreuil Olivier; Boussaha Tarek; Trouilloud Isabelle; Landi Bruno; Housset Martin; Botti Muriel; Rougier Philippe; Belghiti Jacques; Taieb Julien

来源：World Journal of Gastroenterology, 2011, 17(17): 2255-2258.

DOI：10.3748/wjg.v17.i17.2255

• Hepatocellular carcinoma
• Gemcitabine
• Oxaliplatin
• Sorafenib
• Neoadjuvant therapy

This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of a fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.

• 出版日期2011-5-7