Diagnostic values of urine CYFRA21-1, NMP22, UBC, and FDP for the detection of bladder cancer

作者：Jeong Seri; Park Yongjung; Cho Yonggeun; Kim Young Ran; Kim Hyon Suk^*

来源：Clinica Chimica Acta, 2012, 414: 93-100.

DOI：10.1016/j.cca.2012.08.018

• Bladder cancer
• CYFRA 21-1
• FDP
• NMP22
• UBC
• Urinary tumor marker

Background: We compared the diagnostic utilities of CYFRA 21-1, nuclear matrix protein-22 (NMP22), urinary bladder cancer antigen (UBC), and fibrin/fibrinogen degradation products (FOP) for detecting urinary bladder cancer.
Methods: We assayed CYFRA 21-1, NMP22, UBC and FOP from urine samples for 250 subjects. Among them, 54 were diagnosed as bladder cancer, and the remaining 196, which consisted of healthy individuals and patients with hematuria, inflammation/infection, or benign prostate hyperplasia, were assigned to the control group.
Results: Urinary levels of all 4 markers were higher in the bladder cancer group than the control group. The areas under the receiver operating characteristic curves (ROC-AUCs) of CYFRA 21-1, NMP22, UBC and FOP, corrected with urine creatinine concentrations, were 0.90, 0.89, 0.80 and 0.77, respectively, for discriminating bladder cancer from controls. The ROC-AUCs for the combinations of the markers were not significantly higher than those with CYFRA 21-1 or NMP22. NMP22 was the only independent variable for predicting bladder cancer among the four markers in the multivariate analysis.
Conclusions: All 4 tumor biomarkers exhibited diagnostic utility for predicting bladder cancer. Among them, CYFRA 21-1 and NMP22 were the most effective at predicting bladder cancer.

• 出版日期2012-12-24