Determination of Oncogenic Human Papillomavirus (HPV) Genotypes in Anogenital Cancers in Myanmar

作者：Shwe Mu Mu; Thu Hlaing Myat; Aye Khin Saw; Myint Aye Aye; Thida Mya; Mar Khin Shwe; Oo Khin Khin; Aye Khin Sandar; Okada Shigeru; Thant Kyaw Zin

来源：Acta Medica Okayama, 2016, 70(2): 103-110.

• human papillomavirus (HPV)
• ano-genital cancer
• Myanmar
• genotyping of HPV
• cross-sectional study

Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confirmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women's Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism. Overall, 34 of anogenital cancers were HPV-positive. HPV was found in 44.4 of anal (4/9), 36.1 of vulvar (22/61), and 26.7 of penile (8/30) cancers. The most frequent genotypes in anal cancers were HPV 16 (75) and 18 (25). In vulvar cancers, HPV 33 was most common (40.9), followed by 16 (31.8), 31 (22.7), and 18 (4.6). In penile cancers, HPV 16 (62.5) was most common, followed by 33 (25) and 18 (12.5). This is the first report of evidence-based oncogenic HPV genotypes in anogenital cancers among men and women in Myanmar. This research provides valuable information for understanding the burden of HPV-associated cancers of the anus, penis, and vulva and considering the effectiveness of prophylactic HPV vaccination.

• 出版日期2016-4