Stable Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) Subtype a/Subgroup A Endemicity in Amerindians From Northwest Argentina: A Health Problem to Be Resolved

作者：Eirin Maria E^*; Berini Carolina A; Jones Leandro R; Dilernia Dario A; Puca Alberto A; Biglione Mirna M

来源：Journal of Medical Virology, 2010, 82(12): 2116-2122.

DOI：10.1002/jmv.21834

• HTLV-1/2
• epidemiology
• natives
• phylogeny
• northwest argentina

Jujuy province, in Northwest Argentina, is known to be endemic for HTLV-1 infection. Moreover, foci of HTLV-1 associated pathologies have also been described in this region. To gain an insight into the current situation of HTLV-1/2 in this endemic area, a seroprevalence and phylogenetic study was performed among a Kolla community from Abra Pampa city and surroundings. Out of 112 individuals, 11 (9.8%) were confirmed as HTLV-1 positive and no HTLV-2 infection was detected. The phylogenetic analysis of the LTR region showed that all the HTLV-1 sequences belonged to the Cosmopolitan subtype a/transcontinental subgroup A, and were closely related to reference sequences from Peru, Argentina, and the South of Brazil (P = 0.82). Considering the cultural and historical features of this community and in spite of the mandatory detection of anti-HTLV-1/2 antibodies in blood banks since 2005, it would be important to implement new public health measures focused on decreasing HTLV-1 transmission in this endemic area. J. Med. Virol. 82:2116-2122, 2010.

• 出版日期2010-12