New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti

作者：Gulzar Tahsin; Uddin Nizam; Siddiqui Bina Shaheen^*; Naqvi Syed N H; Begum Sabira; Tariq Rajput Muhammed

来源：Phytochemistry Letters, 2013, 6(2): 219-223.

DOI：10.1016/j.phytol.2013.01.006

• Piper nigrum Linn
• Larvicidal activity
• Aedes aegypti L.
• Pipilyasine
• Pipzubedine
• Pipyaqubine

Six bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EIMS, FAB-MS, H-1 and C-13 NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (H-1-H-1 COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method.

• 出版日期2013-5