Acute monocytic leukaemia with t(11;12) (p15; q13) chromosomal changes: A case report and literature review

作者：Hu Jiasheng; Hong Xiuli; Li Zhe; Lu Quanyi^*

来源：Oncology Letters, 2015, 10(4): 2307-2310.

DOI：10.3892/ol.2015.3511

• translocation
• acute leukaemia
• FLT3-ITD
• cytogenetics

Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; 12) (p15; q13) along with a positive FLT3-ITD mutation. The patient had a white blood cell count of 76.41x10(9)/l. Bone marrow morphology revealed that monoblasts accounted for 25.5% of cells, and premonocytes accounted for 49.0%. This patient strongly responded to idarubicin and Ara-c (cytarabine) chemotherapy, which rapidly eliminated the leukaemia cell clones. However, the proliferation rate of the leukaemia cells was high during the intermission of chemotherapy. Subsequently, following two courses of chemotherapy, full haematological remission could not be attained. AML patients with t(11; 12) (p15; q13) combined with FLT3-ITD mutations are expected to have a short life expectancy; however, early haematopoietic stem cell transplantation therapy may improve the treatment outcome for these patients.

• 出版日期2015-10
• 单位厦门大学