An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity

作者：Liang, Jia-Hao; Huo, Xiao-Kui; Cheng, Zhong-Bin; Sun, Cheng-Peng^*; Zhao, Jian-Chao; Kang, Xiao-Hui; Zhang, Tian-Yuan; Chen, Zhong-Jian; Yang, Tian-Mei; Wu, Ying-Ying; Deng, Xiao-Peng^*; Zhang, Yi-Xuan^*

来源：Natural Product Research, 2019, 33(19): 2770-2776.

DOI：10.1080/14786419.2018.1501050

• Drechmeria sp
• indole diterpenoid
• antimicrobial activity
• molecular docking

One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 mu g/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.

• 出版日期2019-10-2
• 单位河北医科大学; 大连医科大学; 河南大学; 文山学院; 云南省农业科学院; 沈阳药科大学