Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase

作者：Hales KG; Fuller MT

来源：Cell, 1997, 90(1): 121-129.

DOI：10.1016/S0092-8674(00)80319-0

The Drosophila melanogaster fuzzy onions (fzo) gene encodes the first known protein mediator of mitochondrial fusion. During Drosophila spermatogenesis, mitochondria in early postmeiotic spermatids aggregate, fuse, and elongate beside the growing flagellar axoneme. fro mutant males are defective in this developmentally regulated mitochondrial fusion and are sterile. fro encodes a large, novel, predicted transmembrane GTPase that becomes detectable on spermatid mitochondria late in meiosis II, just prior to fusion, and disappears soon after fusion is complete. Missense mutations that alter conserved residues required for GTP binding in other GTPases inhibit the fusogenic activity of Fzo in vivo but do not affect its localization. Fzo has homologs of unknown function in mammals, nematodes, and yeast.

• 出版日期1997-7-11