New Glycosides from Dracocephalum tanguticum Maxim

作者：Zeng, Qi; Chang, Ruijie; Qin, Jiangjiang; Cheng, Xiangrong; Zhang, Weidong; Jin, Huizi^*

来源：Archives of Pharmacal Research, 2011, 34(12): 2015-2020.

DOI：10.1007/s12272-011-1202-0

• Dracocephalum tanguticum Maxim
• Glycosides
• Nitric oxide production

Four new glycosides, luteolin-7-methoxy-3'-O-(3 ''-O-acetyl)-beta-D-gluco pyranuronic acid-6 ''-methyl ester (1), benzyl-6[(2E)-2-butenoate]-beta-D-glucopyranoside (2), 2-methoxy-4-(2-propenl-yl)penyl-6-acetate-beta-D-glucopyranoside (3), and 2-methoxy-4-(2-propen-1-yl)peny1-6-[(2E)-2-butenoate]-beta- D-glucopyranoside (4), along with benzyl-beta-D-glucopyranoside (5), 2-methoxy-4-(2-propen-1-yl)penyl-beta-D-glucopyranoside (6), and pectolarigenin (7), were isolated from the whole plant of Dracocephalum tanguticum Maxim. The structures of 1-4 were elucidated by detailed spectroscopic analyses, including HR-ESI-MS and 2D NMR spectroscopic data. The inhibitory effects against nitric oxide production in LPS-stimulated RAW264.7 cells of all seven compounds were also evaluated.

• 出版日期2011-12
• 单位中国人民解放军第二军医大学; 上海交通大学