A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method

作者：Nikalje Milind D^*; Sasikumar Murugesan; Muthukrishnan Murugan

来源：Tetrahedron: Asymmetry , 2010, 21(23): 2825-2829.

DOI：10.1016/j.tetasy.2010.11.011

A practical and highly efficient enantioselective synthesis of (R)-phenoxybenzamine hydrochloride has been described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and source of chirality.

• 出版日期2010-12-8