An efficient ultrasound-promoted one pot synthesis of spiroacenaphthylene pyrazolotriazole and pyrazolophthalazine derivatives

作者：Rezaei Seyed Jamal Tabatabaei; Bide Yasamin; Nabid Mohammad Reza^*

来源：Tetrahedron Letters, 2012, 53(38): 5123-5126.

DOI：10.1016/j.tetlet.2012.07.049

• Spiroacenaphthylene
• Pyrazolotriazole
• Pyrazolophthalazine
• Knoevenagel adduct
• Ultrasound irradiation

A facile and efficient one pot three-component ultrasound-promoted synthesis of spiro pyrazolo compounds has been developed. Employing ethanol as a solvent, assumed to be relatively environmentally benign, and use of an inexpensive and readily available catalyst combined with the advantages of sono-chemistry, such as mild reaction conditions, excellent yield, and short reaction times highlight this synthetic route. The reactions were carried out under both conventional heating and ultrasound-assisted conditions and several reaction parameters are investigated and compared.

• 出版日期2012-9-19