Morphological and Functional Changes in the Thymus and Spleen of Mouse Offspring in the Development of Systemic Inflammatory Response After a Single Immunity Stimulation in Early Pregnancy

作者：Obernikhin S S^*; Yaglova N V

来源：Bulletin of Experimental Biology and Medicine, 2014, 157(6): 812-815.

DOI：10.1007/s10517-014-2673-z

• prenatal exposure
• thymus
• spleen
• lipopolysaccharide
• systemic inflammatory response

We studied morphological and functional changes in the thymus and spleen of mouse offspring subjected to single immune stimulation with concanavalin A at early pregnancy terms against the background of systemic inflammatory response. The offspring was characterized less pronounced accidental involution of the thymus, reduced counts of neutrophils in the marginal zone and red pulp of the spleen, mast cell degranulation, and their reduced content in the red pulp.

• 出版日期2014-10