A novel oxazolidinone antibiotic: RWJ-416457

作者：Cheung Eugene Y^*; Peterson Matthew L; Chiarella Renato; Foxman Bruce M

来源：Acta Crystallographica Section C-Crystal Structure Communications, 2010, 66(5): O249-O251.

DOI：10.1107/S0108270110009339

The crystal structure of the antibiotic drug candidate RWJ-416457 (systematic name: N-{(5S)-3-[4-(5,6-dihydro-2H, 4H-2-methylpyrrolo[3,4-c]pyrazol-5-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl} acetamide), C18H20FN5O3, which belongs to the first new class of antibiotics discovered in the past 30 years, has been determined at 150 K. Each molecule of this drug donates one hydrogen bond to a neighboring molecule and accepts one hydrogen bond to give (O=C-R-N-H center dot center dot center dot O=C-R-N-H center dot center dot center dot)(n) linkages along the b-axis direction. The compound contains a pyrrolopyrazole ring, which, owing to its uncommon structure, has been shown to have particular effectiveness against multi-drug-resistant bacteria.

• 出版日期2010-5