Delayed Radiotherapy for Patients with Localized Prostate Cancer: Validation by Propensity Score Matching

作者：Nakayama Hidetsugu^*; Kanemoto Ayae; Kikuchi Koji; Matsuki Katsuyuki; Tomobe Mitsuro; Tsukamoto Sadamu; Takeshima Hitoshi; Oshiro Yoshiko; Sugahara Shinji; Tokuuye Koichi

来源：Anticancer Research, 2013, 33(4): 1629-1633.

• Prostate cancer
• delayed radiotherapy
• propensity score

Aim: To retrospectively investigate the biochemical outcome following delayed radiotherapy in patients with prostate cancer. Patients and Methods: From July 2000 to November 2008, 144 consecutive patients with localized prostate cancer underwent radiotherapy and androgen-deprivation therapy. Biochemical progression-free survival was compared in patients who began radiotherapy %26gt;6 months (delayed group) with these who began months (non-delayed group) from diagnosis by biopsy. Treatment selection bias was adjusted by the propensity score method. Results: After a median follow-up of 64 months, the 5-year biochemical progression-free survival of the delayed and non-delayed groups was 87.4% (95% confidence interval, CI=69.7-95.1%) and 96.6% (95% CI=89.6-98.9%), respectively (p=0.03). Delayed radiotherapy was the only independent risk factor for biochemical progression (hazard ratio=3.97, 95% CI 1.07-14.7, p=0.04). The results were validated by propensity score analysis. Conclusion: Delaying radiotherapy by %26gt;6 months increases the risk of biochemical progression in patients with localized prostate cancer.

• 出版日期2013-4