Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

作者：Epple Rochelle; Blanes Lucas; Beavis Alison; Roux Claude; Doble Philip^*

来源：Electrophoresis, 2010, 31(15): 2608-2613.

DOI：10.1002/elps.201000128

• Amphetamines
• Capacitively coupled contactless conductivity detection
• CE
• Ecstasy
• Methamphetamine

CE with capacitively coupled contactless conductivity detection (C(4)D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-beta-cyclodextrin (HP beta CD) in a 75 mM acetic acid + 25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C(4)D and UV were 1.3 and 1.0 ppm, respectively. The effects of HP beta CD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed.

• 出版日期2010-8