Processing ulvan into 2D structures: Cross-linked ulvan membranes as new biomaterials for drug delivery applications

作者：Alves Anabela^*; Pinho Elisabete D; Neves Nuno M; Sousa Rui A; Reis Rui L

来源：International Journal of Pharmaceutics, 2012, 426(1-2): 76-81.

DOI：10.1016/j.ijpharm.2012.01.021

• Ulvan
• Membrane
• Dressing
• Medicated dressing
• Drug delivery

The polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step was necessary to render the membrane insoluble in water and stable at physiological conditions. Crosslinked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mechanism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes revealed remarkable ability to uptake water (up to similar to 1800% of its initial dry weight) and increased mechanical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial steady release of the drug - of nearly 49% - followed by slower and sustained release up to 14 days. The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as a wound dressing.

• 出版日期2012-4-15