A Case of Acute Kidney Injury with Marked Hyperuricemia During Mizoribine Administration

作者：Nishino Tomoya; Shinzato Takeaki^*; Ohta Yuuki; Yamashita Hiroshi; Obata Yoko; Shinzato Ken; Kohno Shigeru

来源：Internal Medicine, 2012, 51(10): 1239-1243.

DOI：10.2169/internalmedicine.51.7230

• mizoribine
• acute kidney injury
• acute pancreatitis
• hyperuricemia
• uric acid nephropathy

A 52-year-old woman was diagnosed with Blau syndrome and rheumatoid arthritis and was treated with prednisolone and methotrexate. Joint pain and skin ulcers were poorly controlled; therefore, mizoribine (MZ; 150 mg/day) was administered once daily from March 2011. In early July 2011, the patient was hospitalized because of acute kidney injury (AKI) and acute pancreatitis. We reasoned that AKI resulted from hyperuricemia during MZ administration because serum concentrations of uric acid (31.6 mg/dL) and MZ (trough level, 5.14 mu g/mL) were markedly elevated on admission. MZ should be administered with caution because of the risk of marked hyperuricemia leading to AKI.

• 出版日期2012